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  1. Zheng, W., LaCourse, S., Song, B., Singh, D. K., Khanna, M., Olivo, J., Stern, J., Escudero, J., Vergara, C., Zhang, F., Li, S., Wang, S., Cranmer, L.M., Huang, Z., Bojanowsk, C.M., Bao, D., Njuguna, I., Xiao, Y., Wamalwa, D. C., Nguyen, D. T., Yang, L., Maleche-Obimbo, E., Nguyen, N., Zhang, L., Phan, H., Fan, J., Ning, B., Li, C., Lyon, C. J., Graviss, E. A., John-Stewart, G., Mitchell, C. D., Ramsay, A. J., Kaushal , D., Liang, R., Pérez-Then, E., Hu, T.* Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples. Nature Biomedical Engineering. 2022. 6, 979-991.

  2. Huang, Z., LaCourse, S., Kay A.,  Stern, J., Escudero, J., Youngquist, B., Zheng, W., Vambe, D., Dlamini, M., Mtetwa, G., Cranmer, L., Njuguna, I., Wamalwa, D., Maleche-Obimbo, E., Catanzaro, D., Lyon, C., John-Stewart, G., DiNardo, A., Mandalakas, A., Ning, B.,  Hu, T.* CRISPR Detection of Circulating Cell-free M. tuberculosis DNA in Adults and Children, Including Children with HIV. The Lancet Microbe. 2022, 3(7): E482-492.

  3. Zheng, W., Shu, Q., Mao L., Lyon, C., Li, C., Hu, T.* Nanopore-based disease diagnosis using pathogen-derived tryptic peptides from serum. Nano Today. 2022, 45:101515.

  4. Ning, B., Youngquist, B. M., Li, D. D., Lyon, C. J., Zelazny, A., Maness4, N. J., Tian, D.,  Hu, T.* Rapid detection of multiple SARS-CoV-2 variants of concern by PAM-targeting Mutations. Cell Reports Method. 2022. 2(2):100173.

  5. Ning, B., Chandra, S., Rosen, J., Evan, M., Melvin, A., Lane, P., Ivy, T., Brittany, S., Escarra, M., Stacy, D., Zwezdary, K., Lyon, C., Norton, E., Hu, T.* Evaluation of pathogen specific T-cell activation with a point-of-care on-chip IGRA. ACS Nano. 2022, Accepted.

  6. Ning, B., Huang, Z., Youngquist, B. M, Scott, J. W., Niu, A., Bojanowski, C., M., Zwezdaryk, K. J., Saba, N., S., Fan, J., Yin, X., Cao, J., Lyon, C. J., Li, C., Roy, C. J., Hu, T.* Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in plasma. Nature Nanotechnology. 2021. 16, 1039-1044.

  7. Ning, B., Yu, T., Zhang, S., Huang, Z., Tian, D., Lin, Z., Niu, A., Golden, N., Hensley, K., Threeton, B., Lyon, C. J., Yin, X., Saba, N., Rappaport, J., Wei, Q., Hu, T.* A smartphone-read ultrasensitive and quantitative saliva test for COVID-19. Science Advances. 2021. 7(2): eabe3703.

  8. Huang, Z., Ning, B., Yang, H., Youngquist, B., Niu, A., Lyon, C., Beddingfield, B., Fears, A., Monk, C., Murrell, A., Bilton, S., Linhuber, J., Norton, E., Dietrich, M., Lai, W., Scott, J., Yin, X., Rappaport, J., Robinson, J., Saba, N., Roy, C., Zwezdaryk, K., Zhao, Z., Hu, T.* Sensitive tracking of viral RNA in plasma through all stages of SARS-CoV-2 infection. J. Clinical Investigation. 2021, 131(7):e146031.

  9. Liu, Y., Fan, J., Xu, T., Ahmadinejad, N., Hess, K., Lin, S., Zhang, J., Liu, X., Liu, X., Ning, B., Liao, Z., Hu, T.* Extracellular Vesicle Tetraspanin-8 Expression Predicts Distant Metastasis in Non-Small Cell Lung Cancer after Concurrent Chemoradiation. Science Advances. 2020, 6:11, eaaz6162.

  10. Rodrigues, M., Richards, N., Ning, B., Lyon, C., Hu, T.* Rapid lipid-based normalization of membrane protein expression on extracellular vesicles in complex biological samples. Nano Letters. 2019, 19, 11, 7623-7631 (Cover Story).

  11. Liu, C., Zhao, Z., Fan, J., Lyon, C. J., Wu, H., Nedelokv, D., Zelazny, A.M., Olivier, K.N., Cazares, L.H., Holland, S.H., Graviss, E. A., Hu, T.* Quantification of Circulating M. tuberculosis Antigens for Rapid Diagnosis and Real-time Treatment Monitoring. Proc. Natl. Acad. Sci. U S A.  2017, 114(15):3969-3974. (Highlighted by New England Journal of Medicine)

  12. Liang K., Liu, F., Fan, J., Sun, D., Bernard, D. W., Li, Y., Yokoi, K., Katz, M. H., Koay, E. J., Zhao, Z., Hu, T.* Nanoplasmonic Quantification of Tumor-derived Extracellular Vesicles in Plasma Microsamples for Diagnosis and Treatment Monitoring. Nature Biomedical Engineering. 2017, 1:0021. (Highlighted by Nature Review Gastroenterology & Hepatology)


  1. Bao, D., Maity, S., Zelanzny, A., Lyon, C.,Fan, J. Improving Targeted Mass Spectrometry Data Analysis with Nested Active Machine Learning. 2024, 2300773.

  2. Li, L., Henkle, E., Youngquist, B., Seo, S., Hamed, K., Melnick, D., Lyon, C., Jiang, L., Zelazny, A.,Hu, T., Winthrop, K., Ning, B. Serum cell-free DNA-based detection of Mycobacterium avium complex infection. Am. J. Respir. Crit. Care Med. 2024, 209(10):1246-1254..

  3. Das, S., Lyon, C., Hu, T. A Panorama of Extracellular Vesicle Applications: From Biomarker Detection to Therapeutics. ACS Nano. 2024, 18(14): 9784–9797.

  4. Liao, H., Lyon, C., Ying, B., Hu, T. Climate change, its impact on emerging microbial infectious diseases and new technologies to combat the challenge. Emerging Microbes & Infections. 2024, 13(1):2356143.

  5. Huang G., Zheng, W., Wan, M., Hu, T. Recent Advances to Address Challenges in Extracellular Vesicles-Based Application for Lung Cancer. Acta Pharmaceutica Sinica B. 2024, Accepted.

  6. Li, L., Lyon, C. J., LaCourse, S. M., Zheng, W., Stern, J., Escudero, J. N., Murithi, W., Njagi, L., John-Stewart, G., Hawn, T., Nduba, V., Abdelgaliel, W., Tombler, T., Horne. D., Jiang, L., Hu, T.Sensitive detection of HIV-1 and Mycobacterium tuberculosis peptides in blood for rapid diagnosis of co-infected individuals by immuno-affinity liquid chromatography tandem mass spectrometry. Clinical Chemistry. 2023, 69(12):1409-1419.

  7. Huang, Z., Lyon, C., Wang, J., Lu, S., Hu, T. CRISPR assays for disease diagnosis: progress to and barriers remaining for clinical applications. Advanced Science. 2023, e2301697.

  8. Huang, Z., Zhang, G., Lyon, C., Hu, T., Lu, S. Outlook for CRISPR-based tuberculosis assays now in their infancy. Frontier in Immunology. 2023, 14:1172035. 

  9. Li, L., Wu, J., Lyon, C., Jiang, L., Hu, T. Clinical Peptidomics: Advances in Instrumentation, Analyses, and Applications. BME Frontiers. 2023. 4:0019.

  10. Li, C.Z. and Hu, T. (2022) Nanotechnology Powered CRISPR-Cas Systems for Point of Care Diagnosis and Therapeutic. Research. 2023. 2022:9810237.

  11. Monk, C., Youngquist, B., Brady, A., Shaffer, J., Hu, T., Ning, B., Zwezdaryk, K. Development of a CRISPR-Cas12a rapid diagnostic for human cytomegalovirus. Antiviral Research. 2023. 215:105624.

  12. Toraih, E.A., Fawzy, M.S., Ning, B., Zerfaoui, M., Errami, Y., Ruiz, E.M., Hussein, M.H., Haidari, M., Bratton, M., Tortelote, G.G., Hilliard, S., Nilubol, N., Russell, J.O., Shama, M.A., El-Dahr, S.S., Moroz, K., Hu, T., and Kandil E. A miRNA-Based Prognostic Model to Trace Thyroid Cancer Recurrence. Cancers. 2023. 14(17):4128. 

  13. Maity, S., Mayer, M., Shu, Q., Bao, D., Blair, R., He, Y., Lyon, C., Hu, T., Fischer, T., Fan, J.Cerebrospinal fluid protein markers indicate neuro-damage in SARS-CoV-2-infected non-human primates. Molecular and Cellular Proteomics. 2023, 22(4):100523.

  14. Huang, Z., Lyon, C., Hu, T. CRISPR-based assays for low-resource settings. Nature Reviews Bioengineering. 2023, Accepted.

  15. Li, L., Zhang, L., Montgomery, K., Lyon, C., Hu, T. Advanced Technologies for Molecular Diagnosis of Cancer: State of Pre-Clinical Tumor-Derived Exosome Liquid Biopsies. Materials Today Bio. 2023, 100538. 

  16. Wu, J., Lin, Z., Zou, Z., Wu, M., Hu, T.*, Zhang, Y.* Identifying the Phenotypes of Tumor-Derived Extracellular Vesicles using Size-coded Affinity Microbeads. Journal of the American Chemical Society. 2022, 144(51):23483-91.

  17. Wang, S., Zheng, W., Zhang, L., Yang, L., Wang, T., Saliba, J., Chandra, S., Chandra, S., Li, C., Lyon, C., Hu, T. Monocrystalline labeling enables stable plasmonic enhancement for isolation-free extracellular vesicle analysis. Small. 2022. 2204298.

  18. Yang, L., Liang T., Pierson, L., Wang, H., Fletcher, J., Wang, S.,  Bao, D., Zhang, L., Huang, Z., Zheng, W., Zhang, X., Park, H., Li, Y., Robinson, J., Feehan, A., Lyon, C., Cao, J., Morici, L., Li, C., Roy, C., Yu, X., Hu, T. SARS-CoV-2 epitopes following infection and vaccination overlap known neutralizing antibody sites. Research. 2022. 9769803.

  19. Wei, X., Wang, X., Zhang1, Z., Luo, Y., Wang, Z., Xiong, W., Jain, P., Monnier, J., Wang, H., Hu, T., Tang, C., Albrecht, H., Liu, C. A Click Chemistry Amplified Nanopore (CAN) Assay for Ultrasensitive Quantification of HIV p24 Antigen in Clinical Samples. Nature Communications. 2022. 6852.

  20. Chandra, S., Hu, T. From Prevention to Therapy- A Roadmap of Nanotechnologies to Stay Ahead of Future Pandemics. ACS Nano. 2022, 16, 7, 9985–9993.

  21. Liu, S., Wu, X., Sutapa, C., Lyon, C., Ning, B., jiang, L., Fan, J., Hu, T. Extracellular vesicles: emerging tools as therapeutic agent carriers. Acta Pharmaceutica Sinica B. 2022. In press.

  22. Hu, T., Chen, X. Nano for CRISPR. ACS Nano. 2022, 16, 6, 8505–8506.

  23. Huang, Z., Zhang, L., Lyon, C. J., Ning, B., Youngquist, B. M., Niu, A., Beddingfield, B. J., Maness, N. J., Saba, N. S., Li, C., Roy, C. J., Hu, T. CRISPR-based Assay Reveals SARS-CoV-2 RNA Dynamic Changes and Redistribution Patterns in Non-Human Primate Models. Emerging Microbe & Infections. 2022. 11(1):629-638.

  24. Rutkai, I., Mayer. M., Hellmers, L., Ning, B., Huang, Z., Monjure, C., Coyne, C., Silvestri, R., Golden, N., Hensley, K., Chandler, K., Lehmicke, G., Bix, G., Maness, N., Russell-Lodrigue, K., Hu, T., Roy, C., Blair, R., Bohm, R., Doyle-Meyers, L., Rappaport, J., Fisher, T. Neuropathology and Virus in Brain of SARS-CoV-2 Infected Non-Human Primates. Nature Communications. 2022. 13:1745.

  25. Alwarappan, S., Nesakumar, N., Sun, D., Hu, T.*, Li, C.* 2D metal carbides and nitrides (MXenes) for Sensors and Biosensors. Biosensors and Bioelectronics. 2022. 205:113943.

  26. Shu, Q., Rajagopal, M., Fan, J., Zhan L., Kong X, He Y., Rotcheewaphan, S., Lyon, C. J., Sha, W., Adrian M. Zelazny, A. M., Hu, T. Peptidomic Analysis of Mycobacterial Secreted Proteins Enables Species Identification. View. 2022, 3:20210019.

  27. Shu, Q., Liu, S., Alonzi, T., LaCourse, S. M., Singh, D., Bao, D., Wamalwa, D., Jiang, L., Lyon, C. J., John-Stewart, G., Kaushal, D., Goletti, D., Hu, T. Assay Design for Unambiguous Identification and Quantification of Circulating Pathogen-derived Peptide Biomarkers. Theranostics. 2022. 12(6):2948-2962.

  28. Toraih, E.A., Fawzy, M.S., Ning, B., Zerfaoui, M., Errami, Y., Ruiz, E.M., Hussein, M.H., Haidari, M., Bratton, M., Tortelote, G.G., Hilliard, S., Nilubol, N., Russell, J.O., Shama, M.A., El-Dahr, S.S., Moroz, K., Hu, T., Kandil, E. A miRNA-Based Prognostic Model to Trace Thyroid Cancer Recurrence. Cancers. 2022, 14, 4128.

  29. Oguntoye, I., Simone, B., Padmanabha, S., Hartfield, G., Amrollahi, P., Hu, T., Ollanik, A., Escarra, M. Silicon Nanodisk Huygens Metasurfaces for Portable and Low-Cost Refractive Index and Biomarker Sensing. ACS Applied Nano Materials. 2022. 5(3): 3983-3991.

  30. Hu, Q., Zhang, S., Yang, Y., Yao, J., Tang, W., Lyon, C., Hu, T., Wan, M. Extracellular vesicles in the pathogenesis and treatment of acute lung injury. Military Medical Research. 2022, In press.

  31. Sun, D., Zhao, Z., Spiegel, S., Liu, Y., Fan, J., Amrollahi, P., Lyon, C. J., Wan, M., Hu, T. Dye-free spectrophotometric measurement of nucleic acid-to-protein ratio for cell selective extracellular vesicle discrimination. Biosensors and Bioelectronics. 2021. 179: 113058.

  32. Shu, Q., Kenny, T., Fan, J., Lyon, C., Cazares, L., Hu. T. Species-specific Quantification of Circulating Ebolavirus Burden using VP40-derived Peptide Variants. PLOS Pathogens. 2021. 17(11): e1010039.

  33. Nakao, Y., Amrollahi, P., Parthasarathy, G., Mauer, A. S., Sehrawat, T. S., Vanderboom, P., Nair, S., Nakao, K., Allen, A. M., Hu, T.*, Malhi, H.* Circulating extracellular vesicles are a biomarker for NAFLD resolution and response to weight loss surgery. Nanomedicine: BME. 2021. 36:102430. 

  34. Rao, J., Hu, T., Teck, L., Han, D. Mechanics of cancer and cancer cells – a 4th dimension? Frontier in Cell and Development Biology. 2021, 9:775012.

  35. Liu, W., Zhu, X., Mozneb, M., Nagahara, L., Hu, T., Li, C. Lighting up ATP in cells and tissues using a simple aptamer-based fluorescent probe. Microchimica Acta. 2021, 188(10):352.

  36. Amrollahi, P., Zheng, W., Monk, C., Li, C., Hu, T. Nanoplasmonic sensor approaches for sensitive detection of disease-associated exosomes. ACS Applied Bio Materials. 2021, 4 (9): 6589–6603.

  37. Niu, A., Ning, B., Socola, F., Safah, H., Reynolds, T., Ibrahim, M., Safa, F., Alfonso, T., Luk, A., Mushatt, D., Hu, T., Saba, N. S. COVID-19 in Patients with Hematological Malignancies: High False Negative Rate with High Mortality. Blood. 2020, 136 (1): 6-7.

  38. He, Y., Lyon, C. J., Nguyen D. T., Liu, C., Sha, W. Graviss, E., Hu, T.* Serum-based diagnosis of pediatric tuberculosis by assay of Mycobacterium tuberculosis factors: a retrospective cohort study. J. Clin. Micro. 2021. 59(2): e01756-20.

  39. Chen, X., Hu, T.* Strategies for advanced personalized tuberculosis diagnosis. Precision Clinical Medicine. 2021. 4(1): 35-44.

  40. Hu, T.*, Walfrom, J. E., Srivastava, S. * Extracellular Vesicles in Cancer Detection: Hopes and Hypes. Cell: Trends in Cancer. 2021, 7(2): 122-133.

  41. Hu, T.*, Frieman, M.*, Walfram, J.* Insights from nanomedicine into chloroquine efficacy against COVID-19. Nature Nanotechnology. 2020, 15:247-249.

  42. Hu, Q., Fletcher, J. K., Tang, W., Lyon, C. J., Wan, M., Hu, T.* Macrophages and secreted EV-mediated interaction loops in inflammatory disease. Acta Pharmaceutica Sinica B. 2020. 11(6): 1493-1512.

  43. He, X., Howard, B. A., Liu, Y., Neumann, A. K., Li, L., Menon, N., Roach, T., Kale, S. D., Samuels, D. C., Li, H., Kite, T., Kita, H., Hu, T., Luo, M., Jones, C. N., Okaa, U., Squillace, D. L., Klein, B. S., Lawrence, C. B. LYSMD3: a mammalian pattern recognition receptor for chitin. Cell Report. 2021. 36: 109392.

  44. Hu, Q., Lyon, C. J., Fletcher, J. K., Tang, W., Wan, M., Hu, T.* Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses. Acta Pharmaceutica Sinica B. 2021. 11(6): 1492-1512.

  45. Niu, A., Ning, B., Socola, F., Safah, J. H., Reynolds, T., Ibrahim, M., Safa, F., Luk A. T., Mushatt, D. M., Hu, T., Saba N. S. High mortality with High false negative rate: COVID-19 infection in patients with hematologic malignancies. Leukemia Research. 2021, 160:106582.

  46. Tian, D., Lin, Z., Kriner, E. M., Esneault, D. J., Tran, J., DeVoto, J. C., Okami, N., Greenberg, R., Yanofsky, S., Ratnayaka, S., Tran, N., Livaccari, M., Lampp, M., Wang, N., Tim, S., Norton, P., Scott, J., Hu, T., Garry, R., Hamm, L., Delafontaine, P., Yin, X. M. Ct Values do not Predict SARS-CoV-2 Transmissibility in College Students. J Mol Diagn. 2021. 21:00163-X. 

  47. Jain, S. Nehra, M., Kumar, R., Dilbaghi, N., Hu, T., Kumar, S., Kaushik, A., Li, C. Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases. Biosensors and Bioelectronics. 2021. 179:113074.

  48. Mao, L., Lacourse, S., Kim, S., Ning, B., Bao, D., Fan, J., Sun, Z., Nackman, S., Mitchelle, C., Hu, T.* Evaluation of a blood-based antigen test for tuberculosis in HIV-exposed children younger than 5 years. BMC Medicine. 2021, 19:113.

  49. Liu, J., Wan, M., Lyon, C., Hu, T.* Nanomedicine therapies modulating macrophage dysfunction: a potential strategy to attenuate cytokine storms in severe infections. Theranostics 2020, 10(21): 9591-9600.

  50. Sun, D., Lyon, C., Hu, T.* Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification darkfield microscope. Journal of Material Chemistry B 2020, 8: 5416-5419.

  51. Moss, D.L., Song, K., Wanek, A.G., Shu, Q., Hu, T., Kolls, J.K., Mettu, R.R., Landry, S.J. Destabilization of exotoxin A diminishes serum antibody titer and affinity maturation by reducing peptide-MHCII abundance. J. Immunology 2020, 204 (1 Supplement) 217.17.

  52. Beddingfield, B., Iwanaga, N., Zheng, W., Roy, C.J. Hu, T., Kolls, J., Bix, G. The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection. J Am Coll Cardiol. 2020, 06(15):153387.

  53. Pal, P., Ibrahim, M., Niu, A., Zwezdaryk, K.J., Tatje, E., Robinson, W.R., IV, Ko, L., Satyavarapu, I., Jones, W.E., Nachabe, A., Luk, A., Mushatt, D.M., Halvorson, K., Denson, J.L., Smith, C.C., III, Simeone, F., Davis, G., Gill, S.K., McDougal, A., Vigh, A.S., Peterson, T.G., Ning, B., Hu, T., Socola, F., Robinson, J., Safah, H. and Saba, N.S. Safety and Efficacy of COVID-19 Convalescent Plasma in Severe Pulmonary Disease, A Report of Seventeen Patients. Transfusion Medicine. 2020, 1(3):217-220.

  54. Niu, A., McDougal, A., Ning, B., Safa, F., Luk, A., Mushatt, D., Fusco, D., Nachabe, A., Zwezdaryk, K., Robinson, J., Socola, F., Safah, H., Hu, T., Saba, N. S. COVID-19 in allogeneic stem cell transplant: high false-negative probability and role of CRISPR and convalescent. Bone Marrow Transplantation 2020, 55:2354-2356.

  55. Huang, Z., Tian, D., Liu, Y., Lin, Z., Lyon, C., J., Lai, W., Fusco, D., Drouin, A., Yin, X., Hu, T.*, Ning, B.* Ultra-sensitive and high-throughput CRISPR-powered COVID-19 diagnosis. Biosensor and Bioelectronics 2020. 164: 112316.

  56. Sehrawat, T. S., Arab, J. P., Liu, M.,  Amrollahi, P., Wan, M., Fan, J., Nakao, Y., Dasgupta, D., Liao, C.,  Navarro-Corcuera, A., Pose, E., He, L.,  Mauer, A., Ventura-Cots, M., Bataller, R. A., Sanyal, A., J., Chalasani, N. P., Heimbach, J. K., Watt, K. D., Gores, G. J.,  Gines, P., Kamath, P. S., Simonetto, D. A., Hu, T., Shah, V. H., Malhi, H. Circulating EVs carrying sphingolipid cargo for the diagnosis and dynamic risk profiling of alcoholic hepatitis. Hepatology. 2020, 73(2):571-585.

  57. Shu, Q., Li, M., Shu, L., An, Z., Wang, J., Lv, H., Yang, M., Cai, T., Hu, T., Fu, Y., Yang, F. Large-scale Identification of N-linked Intact Glycopeptides in Human Serum using HILIC Enrichment and Spectral Library Search. Mol Cell Proteomics. 2020, 19(4):672-689.

  58. Hu, Q., Su, H., Li, J., Lyon, C., Tang, W., Wan, M., Hu, T.* Clinical Applications of Exosome Membrane Proteins. Precision Clinical Medicine. 2020, 3(1): 54–66.

  59. Wan, M., Spiegel, S., Lyon, C., Hu, T.* Tumor-derived exosomes (TEXs): how to avoid the sting in the tail. Medicinal Research Reviews. 2020, 40(1): 385-412 (Cover Story).

  60. Liu, Y., Gu, Y., Lyon, C. J., Fan, J., Koay, E., Katz, M., Han, H., Von Hoff, D., Hu, T.*.  Circulating levels of hydroxylated bradykinin function as an indicator of tissue HIF-1α expression. Science Bulletin. 2020,65(18): 1570-1579.

  61. Hu, X., Chen, H., Liao, S., Bai, H., Gupta, S., Zhou, Y., Zhou, J., Jiao, L., Wu, L., Wang, M., Chen, X., Zhou, Y., Lu, X., Hu, T., Zhang, Z., Ying, B. LncRNA and predictive model for improving the diagnosis of clinically diagnosed pulmonary tuberculosis. Journal of Clinical Microbiology, 2020, 58(7): e01973-19.

  62. Amrollahi P., Rodrigues M., Lyon, C. J., Goel, A., Han, H., Hu, T.* Ultra-sensitive automated profiling of EpCAM expression on tumor-derived extracellular vesicles. Frontiers in Genetics, 2019, 10:1273.

  63. Zhang, F., Lyon, C. J., Fan, J., Hu, T.* A cathepsin B-dependent cleavage product of serum amyloid A identifies patients with chemotherapy-related cardiotoxicity. ACS Pharmacology and Translational Science. 2019, 2, 5, 333-341 (Cover Story).

  64. Wan, M., Wang, Y., Zhan, L., Fan, J., Hu, T.* MALDI-TOF mass spectrometry-based quantification of C-peptide in diabetes patients. European Journal of Mass Spectrometry. 2019, 26(1):55-62.

  65. Deng, Z., Zhao, Z., Basilio, J., Ye, Y., Mann, K., Fu, J., Gu, Y., Wu, X., Chiao, P., Hu, T.* Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection. Nano Research. 2019, 12(6): 1445-1452.

  66. Hu, T.* Nickel affinity: A sensible approach for extracellular vesicles isolation? Lancet: EBioMedicine. 2019, 44:14-15.

  67. Zhao, Z., Ning, B. Lyon, C., Hu, T.* Extracellular vesicles as cancer liquid biopsies: from discovery, validation, to clinical application. Lab-on-a-Chip. 2019, 19(7):1114-1140 (Cover Story).

  68. Droll, S. H., Hsu, Y. M. S., Drake, S. K., Kim, A., Wang, W., Calvo, K. R., Cao, Z., Hu, T., Zhao, Z. Differential Processing of High‐Molecular‐Weight Kininogen during Normal Pregnancy. Rapid Communications in Mass Spectrometry. 2019 Aug 14.

  69. Wan, M., Sun, D., Lyon, C., Hu, T.* Using Nanoplasmon-enhanced scattering and low-magnification microscope imagery to quantify pathogen-driven exosome in micro amount of plasma. J Vis Exp. 2019, (147), e59177.

  70. Liu, C., Lyon, C. J., Deng, Z., Walters, E., Li, Y., Zhang, L., Hesseling, A., Graviss, E. A., Hu, T.* Clinical evaluation of a blood assay to diagnose paucibacillary tuberculosis via bacterial antigens. Clinical Chemistry 2018, 64(7): 1 (Cover Story).

  71. Fan, J., Wei, Q., Koay, E. J., Bernard, P.W., Kai, M., Borsoi, C., Bernard, D.W., Zhang, N., Katz, M.H., Yokoi, K., Zhao, Z., Hu, T.* Chemoresistance transmission via exosome-mediated EphA2 transfer in pancreatic cancer. Theranotics.  2018, 8(21):5986-5994 (Cover Story).

  72. Rodrigues, M., Fan, J., Lyon, C. J., Wan, M., Hu, T.* Role of Extracellular Vesicles in Viral and Bacterial Infections: Pathogenesis, Diagnostics, and Therapeutics. Theranostics 2018, 8(10): 2709-2721.

  73. Zou, R., Cao, W., Chong, L., Hua, W., Xu, H., Mao, Y., Page, J., Shi, R., Xia Y., Hu, T., Zhang, W., Ouyang, Z. Point-of-Care Tissue Analysis Using Miniature Mass Spectrometer. Analytical Chemistry, 2018, 91, 1157-1163.

  74. Yang, J., Xu, T., Gomez, D. R., Yuan, X., Nguyen, Q., Jeter, M., Song, Y., Komaki, R., Hu, T., Hahn, S., Liao, Z. Nomograms incorporating genetic variants in BMP/Smad4/ Hamp pathway to predict disease outcomes after definitive radiotherapy for non-small cell lung cancer. Cancer Medicine 2018; 7(6):2247–2255.

  75. Zhang, W., Shu, Q., Zhao, Z., Fan, J., Lyon, C. J., Zelazny, A., Hu, T.* Antigen 85B peptidomic analysis allows species-specific mycobacterial identification. Clinical Proteomics 2018, 15:1.

  76. Sun, D., Hu T.*. A low cost mobile phone dark-field microscope for nanoparticle-based quantitative studies. Biosensors & Bioelectronics. 2018, 99:513-518.

  77. Sun, D., Hu, T.* A low cost mobile phone-based dark-field microscope for nanoparticle-based quantitative studies. Biosensors and Bioelectronics 2017, 15;99:513-518.

  78. Fan, J., Zhang, H., Nguyen, D., Lyon, C. J., Mitchell, C. D., Zhao, Z., Graviss, E. A., Hu, T.* Rapid diagnosis of new and recurrent tuberculosis by quantification of circulating antigen in HIV-infected adults in the Greater Houston Metropolitan area: a retrospective cohort study. BMC Medicine 2017, 15:188.

  79. Wu, B., Ouyang, Z., Lyon, C. J., Zhang, W., Clift, T., Bone, C., Zhao, Z., Kimata, J., Hu, T.* Plasma C4b peptide levels and HLA-B*57 genotype are associated with spontaneous HIV suppression in HIV-1-infected patients. ACS Infect. Dis. 2017, 3 (12): 880–885.

  80. Liang, K., Wu, H., Hu, T., Li, Y. Mesoporous silica chip: enabled peptide profiling as an effective platform for controlling bio-sample quality and optimizing handling procedure. Clinical Proteomics. 2017, 13(1), 34.

  81. Li, H., Yang, S., Yu, G., Shen, L., Fan, J., Xu, L., Zhang, H., Zhao, N., Zeng, Z. Hu, T., Wen, J., Zu, Y. Aptamer internalization via endocytosis inducing S-phase arrest and priming Maver-1 lymphoma cells for cytarabine chemotherapy. Theranostics. 2017, 7(5): 1204-1213.

  82. “Circulating peptidome and tumor-resident proteolysis” Fan, J., Ning, B., Lyon, C., Hu, T.* Enzyme, edited by Dr. Tony Hu & Dr. Fuyu Tamanoi, 2017 Academic Press/Elsevier.

  83. Book: Peptidomics of Cancer-Derived Enzyme Products, The Enzymes: Volume 42 edited by Dr. Tony Hu & Dr. Fuyu Tamanoi, 2017 Academic Press/Elsevier.

  84. Sun, D., Fan, J., Liu, C., Liu, Y., Bu, Y., Lyon, C. J., Hu, T.* A noise reduction method for quantifying nanoparticle light scattering in low magnification dark-field microscope far-field images. Anal. Chem. 2016, 88(24): 12001-12005.

  85. Li, Y., Hu, T.* Decoding the Blood Peptidome as a New Biomarker Resource for Cancer Detection. MOJ Proteomics Bioinform. 2016, 3(5):00099.

  86. Wang, J., Dong, A., Liu, G., Anderson, G.J., Hu, Y., Shi, J., Hu, T., Nie G. Correlation of serum hepcidin levels with disease progression in hepatitis B virus-related disease assessed by nanopore film based assay. Sci. Rep. 2016, 6:34252.

  87. Zhu, L., Olsen, R., Horstmann, N., Shelburne, S., Fan, J., Hu, T., Musser, J. Intergenic VNTR Polymorphism Upstream of rocA Alters Toxin Production and Enhances Virulence in Streptococcus pyogenes. Infect. Immun. 2016, 84(7): 2086-93.

  88. Qian, X., Nguyen, D.T.M., Li, Y., Lyu, J., Graviss, E.A., Hu, T.* Predictive value of serum bradykinin and desArg9-bradykinin levels for chemotherapeutic responses in active tuberculosis patients: A retrospective case series. Tuberculosis. 2016, pii: S1472-9792 (16): 30407-3.

  89. Hu, T. * Can Sugarcoated Fingerprints be used to Identify Lurking Viruses? Proteomics. 2016, 16: 1947-1948.

  90. Mi, Y., Mu, C., Wolfram, J., Deng, Z., Hu, T., Liu, X., Blanco, E., Shen, H., Ferrari, M. A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis. Adv Healthc Mater. 2016, Apr; 5(8): 936-46.

  91. Ma, X., Chong, L., Tian, R., Shi, R., Hu, Y., Ouyang, Z., Xia, Y. Identification and quantitation of lipid C=C location isomers: a shotgun lipidomics approach coupled with photochemical reaction. Proc. Natl. Acad. Sci. U S A. 2016,113 (10): 2573-8.

  92. Fan, J., Tea, M., Ma, L., Meng, Q., Hu, T. *, Singer, C., Ferrari, M. * Profiling of Cross-Functional Peptidases Regulated Circulating Peptides in BRCA1 Mutant Breast Cancer. J Proteomics Res 2016, 15(5): 1534-45.

  93. Ren, Y., Wang, R., Gao, L., Li, K., Zhou, X., Guo, H., Liu, C., Han, D., Tian, J., Ye, Q., Hu, T., Sun, D., Yuan, X., Zhang, N. Sequential co-delivery of miR-21 inhibitor followed by burst release doxorubicin using NIR-responsive hollow gold nanoparticle to enhance anticancer efficacy, Journal of Controlled Release. 2016, 228(28): 74-86.

  94. Du, Y., Hu, T., Xia, Y., Ouyang, Z. Power Normalization for Mass Spectrometry Data Analysis and Analytical Method Assessment. Anal. Chem., 2016, 88 (6), pp 3156–3163.

  95. Huang, H., Tao, L., Liu, F., Ji, L., Hu, T., Cheng, M., Chen, P., Akinwande, D. Chemical-Sensitive Graphene Modulator with Memory Effect for Internet-of-Things Applications. Nature: Microsystems & Nanoengineering 2016, 2:16018.

  96. Khaled, S. Z., Cevenini, A., Yazdi, I. K., Parodi, A., Evangelopoulos, M., Corbo, C., Scaria, S., Hu, T., Haddix, S. G., Corradetti, B. Salvatore, F., Tasciotti, E. One-pot synthesis of pH-responsive hybrid nanogel particles for the intracellular delivery of small interfering RNA. Biomaterials 2016, 87:57-68.

  97. Deng, Z., Li, Y., Fan, J., Wang G., Li, Y., Zhang Y., Cai G., Shen, H., Hu, T.* Circulating Peptidome to Indicate the Tumor-resident Proteolysis. Scientific Reports. 2015, 5:9327.

  98. Wang, J., Liu, G., Xu, Z., Dai, J., Song, P., Shi, J., Hu, T., Hu, Z., Nie, G., Chan, Y., Zhao, Y. Hepcidin levels in hyperprolactinemic women monitored by nanopore thin film based assay: Correlation with pregnancy-associated hormone prolactin. Nanomedicine: NBM. 2015, 11(4): 871-878.

  99. Xu, Q., Hu, T.* Circulating peptidomics: a promising approach for the diagnosis and treatment of human cancers. Clin. Lab. Inter. 2015; April.

  100. Zhang, P., Wei, Y., Wang, L., Debeb, B. G., Yuan, Y., Zhang, J., Yuan, J., Wang, M., Chen, D., Sun, Y., Woodward, W. A., Liu, Y., Dean, D. C., Liang, H., Hu, T., Ang, K. K., Hung, M. C., Chen, J., Ma, L. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1, Nature Cell Bio. 2014, 16(9): 864-875.

  101. Zhang, P., Wang, L., Rodriguez-Aguayo, C., Yuan, Y., Debeb, B. G., Chen, D., Sun, Y., You, M. J., Liu, Y., Dean, D. C., Woodward, W. A., Liang, H., Yang, X., Lopez-Berestein, G., Sood, A. K., Hu, T., Ang, K. K., Chen, J., Ma, L. miR-205 acts as a tumor radiosensitizer by targeting ZEB1 and Ubc13, Nature Communications. 2014, 5:5671.

  102. Li, Y., Li, Y., Chen, T., Kuklina, A. S., Bernard, P., Esteva, F. J., Shen, H., Hu, T.* Circulating Proteolytic Products of Carboxypeptidase N for Early Detection of Breast Cancer. Clin. Chem. 2014, 60(1): 233-242. PMID: 24146311.

  103. Hu, T.  Multidisciplinary Efforts Driving Translational Theranostics. Theranostics. 2014; 4(12):1209-12 10.

  104. Zhao, H., Li, Y., Hu, T. * Nanotechnologies in Glycoproteomics. Clin. Proteomics. 2014, 11:21.

  105. Fan, J., Niu, S., Dong, A., Shi, J., Wu, H. J., Fine, D. H., Tian, Y., Zhou, C., Liu, X., Sun, T., Anderson, G. J., Ferrari, M., Nie, G., Hu, T. *, Zhao, Y. * Nanopore Film based Enrichment and Quantification of Low Abundance Hepcidin from Human Bodily Fluids. Nanomedicine: NBM. 2014; 10(5): 879-888. (Highlighted by Science Translational Medicine)

  106. Wu, H. J., Li, Y., Fan, J., Deng, Z., Hu, Z., Liu, X., Graviss, E. A., Ma, X., Hu, T.* Antibody-Free Detection of M. tuberculosis Antigen Using Customized Nanotraps. Anal. Chem. 2014; 86 (4), pp 1988–1996. DOI: 10.1021/ac4027669

  107. Shah, P., Zhu, X., Chen, C., Hu, T., Li, C. Z.  Lab-on-chip device for single cell trapping and analysis.  Biomed. Microdevice. 2014; 16(1): 35-41.

  108. Huang H., Zhao P., Chen P., Ren Y., Liu X., Hu T., Akinwande D. RFID Tag Helix Antenna Sensors for Wireless Drug Dosage Monitoring.  Translational Engineering in Health and Medicine, IEEE Journal of, 2014, 2(1): 1-8.

  109. Wang Z., Wu H. J., Fine D., Schmulen J., Hu T., Godin B., Zhang J. X., Liu X. Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles. Lab Chip. 2013, 2879-2882.

  110. Srinivasan S., Alexander J. F., Driessen W. H., Leonard F., Hu T., Liu X., Arap W., Pasqualini R., Ferrari M., Godin B. * Bacteriophage Associated Silicon Particles: Design and Characterization of a Novel Theranostic Vector with Improved Payload Carrying Potential. J. Mater. Chem. B, 2013, 1:5218-5229.

  111. Fan J., Huang Y., Finoulst I., Wu H. J., Deng Z., Xu R., Xia X., Ferrari M., Shen H., Hu T.* Serum Peptidomic Biomarkers for Pulmonary Metastatic Melanoma Identified by means of a Nanopore-based Assay. Cancer Letters. 2013. Nov 27. pii:S0304-3835(12)00658-1.

  112. Fine D., Grattoni A., Goodall R., Bansal S. S., Chiappini C., Hosali S., van de Ven A. L., Srinivasan S., Liu X., Godin B., Brousseau L., Yazdi I. K., Fernandez-Moure J., Tasciotti E., Wu H. J., Hu T., Klemm S., Ferrari M. Silicon Micro- and Nanofabrication for Medicine. Adv. Healthcare Mater. 2013; 2192-2659.

  113. Grattoni A., Tasciotti  E., Fine D., Fernandez-Moure J. S., Sakamoto J., Hu T., Weiner B., Ferrari M., Parazynski S. Nanotechnologies and Regenerative Medical Approaches for Space and Terrestrial Medicine. Aviat Space Environ Med. 2013 Volume 83, No. 11 pp 1-12.

  114. Fan J., Deng X., Gallagher J. W., Huang H., Huang Y., Wen J., Ferrari M., Shen H., Hu T.*  Monitoring the progression of metastatic breast cancer on nanoporous silica chips. Phil. Trans. A RSC 2012, 1967:2433-2447.

  115. Fan J., Gallagher J. W., Wu H. J., Landry M. G., Sakamoto J., Hu T.* Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery. J Vis Exp 2012 (62): e3876.

  116. Zhang, W., Rosano-Ortega, G., Hu, T., Bai, L., Qin, L. “New Investigation in PVP-Mediated Synthesis of Noble Metallic Nanomaterials” J. Nanosci. Nanotechnol. 2012; 12(3): 2634-2639.

  117. Grattoni, A., Tasciotti, E., Fine, D., Fernandez-Moure, J., Sakamoto, J., Hu, T., Ferrari, M., Parazynski, S. * “Nanotechnologies and Regenerative Medical Approaches for Space and Terrestrial Medicine.” Aviation, Space, and Environmental Medicine. 2012; 83(11):1-12.

  118. Huang H., Nieman K., Chen P. Y., Hu, T., Akinwande D. Properties and Applications of Electrically Small Folded Ellipsoidal Helix Antenna. IEEE Antennas and Wireless Propagation Letters, 2012, 11:678-681.

  119. Sharma T#, Hu T#, Stoller M, Feldman M, Ruoff R S, Ferrari M, Zhang X.  Mesoporous Silica as Membrane for Ultra-Thin Implantable Direct Glucose Fuel Cells, Lab-on-a-chip, 2011, 11: 2460-2465. (# Shared first authorship)

  120. Zhou M., Hu T., Ferrari M., Xie Z. Self-Assembled Zinc/Copper Hydroxide Carbonates with Tunable Hierarchical Nanostructure, Journal of Nanotechnology and Nanoscience, 2011, 11: 1-5. (Cover story)

  121. Hu T., Gopal A., Lin K., Peng Y., Tasciotti E., Zhang X., Ferrari M. High throughput enrichment of doi:10.1063/1.3528237 Small Proteins from Complex Biological Mixture Based on Porous Microchips. Biomicrofluidics, 2011, 5, 013410. doi:10.1063/1.3528237

  122. Hu, T., Peng, Y., Lin, K., Shen, H., Brousseau, L.C., Sakamoto, J., Sun, T., Ferrari, M. Surface Engineering on Mesoporous Silica Chips for Enriching Low Molecular Weight Phosphorylated  Proteins, Nanoscale, 2011, 3, 421-428.

  123. “Cardiovascular nanomedicine: challenges and opportunities” Godin B., Hu T., La Francesca S., Ferrari M. Molecular & Translational Vascular Medicine, edited by Dr. Monte Willis & Dr. Jonathon Homeister, 2011 Humana Press.

  124. “Morphology control of nanotextured drug carriers” Hu Y., Lin K.. Mass transport of nanocarriers, edited by Dr. Rita Sedra, 2011 Pan Stanford Publishing Pte. Ltd.

  125. “Nanotechnology Towards Advancing Personalized Medicine” Sakamoto J. H., Godin B., Hu T., Blanco E., Van de Ven A, Vellaichamy A., Murphy M. B., La Francesca S., Schuenemeyer T., Given B., Meyn, A., Ferrari M. Handbook of Personalized Medicine: Advances in Nanotechnology, Drug Delivery and Therapy, 2011 Pan Stanford Publishing Pte. Ltd..

  126. Hu T., Bouamrani A., Tasciotti E., Li L., Liu X., Ferrari M. Tailoring of the nanotexture of mesoporous silica films and their functionalized derivatives for selectively harvesting low molecular weight protein. ACS Nano. 2010 Jan 26; 4(1):439-451.

  127. Bouamrani A.#, Hu T.#, Tascioti E., Li L., Chiappini C., Liu X., Ferrari M. Mesoporous silica chips for selective enrichment and stabilization of low molecular weight proteome. Proteomics. 2010 Feb; 10(3):496-505. (# Shared first authorship)

  128. Hu T., Peng Y., Brousseau L., Bouamrani A., Liu X., Ferrari M. Nanotexture optimization by oxygen plasma of mesoporous silica thin film for enrichment of low molecular weight peptides captured from human serum. Science in China B. 2010, 53(11): 1-8.

  129. Blinka E., Loeffler K., Hu T., Gopal A., Hoshino K., Lin K., Liu X., Ferrari M., Zhang J.X. Enhanced microcontact printing of proteins on nanoporous silica surface. Nanotechnology. 2010 Oct; 21(41): 415302.  

  130. Fan J., Yin J., Ning B., Wu X., Hu T., Ferrari M., Anderson G. J., Wei J., Zhao Y., Nie G. Direct evidence for catalase and peroxidase activities of ferritin-platinum nanoparticles. Biomaterials, 2010, 32(6): 1611-8.

  131. Sakamoto J. H., van de Ven A. L., Godin B., Blanco E., Serda R. E., Grattoni A., Ziemys A., Bouamrani A., Hu T., Ranganathan S. I., DeRosa E., Martinez J. O., Smid C. A., Buchanan R. M., Lee S-Y, Srinivasan S., Landry M., Meyn A., Tasciotti E., Liu X., Decuzzi P., Ferrari M. Enabling individualized therapy through nanotechnology [review]. Pharmacol Res. 2010 Aug;62(2):57-89.

  132. Hu T., Fine D. H., Tasciotti E., Bouamrani A., Ferrari M. Nanodevices in diagnostics [overview]. Wiley Interdiscip Rev [WIRES] Nanomed Nanobiotechnol. 2010 Mar 12.


  1. Fine D., Grattoni A., Goodall R., Bansal S. S., Chiappini C., Hosali S., van de Ven A. L., Srinivasan S., Liu X., Godin B., Brousseau L., Yazdi I. K., Fernandez-Moure J., Tasciotti E., Wu H. J., T. Y. Hu., Klemm S., Ferrari M. Silicon Micro- and Nanofabrication for Medicine. Adv. Healthcare Mater2013; 2192-2659 DOI: 10.1002/adhm. 201200214.

  2. Grattoni A., Tasciotti  E., Fine D., Fernandez-Moure J. S., Sakamoto J., T. Y. Hu., Weiner B., Ferrari M., Parazynski S. Nanotechnologies and Regenerative Medical Approaches for Space and Terrestrial Medicine. Aviat Space Environ Med2013 Volume 83, No. 11 pp 1-12. PMID: 23156089.

  3. Sakamoto J. H., van de Ven A. L., Godin B., Blanco E., Serda R. E., Grattoni A., Ziemys A., Bouamrani A., T. Y. Hu., Ranganathan S. I., DeRosa E., Martinez J. O., Smid C. A., Buchanan R. M., Lee S-Y, Srinivasan S., Landry M., Meyn A., Tasciotti E., Liu X., Decuzzi P., Ferrari M. Enabling individualized therapy through nanotechnology [review]. Pharmacol Res2010 Aug;62(2):57-89.

  4. T. Y. Hu., Fine D. H., Tasciotti E., Bouamrani A., Ferrari M. Nanodevices in diagnostics [overview]. Wiley Interdiscip Rev [WIRES] Nanomed Nanobiotechnol2010 Mar 12 [e-pub ahead of print]. NIHMS217748; NIHMS217647; PMID 20229595; doi: 10.1002/wnan.82.


  1. T. Y. Hu.  Multidisciplinary Efforts Driving Translational Theranostics. Theranostics2014; 4(12):1209-1210.

  2. Xu, Q., T. Y. Hu. Circulating peptidomics: a promising approach for the diagnosis and treatment of human cancers. Clin. Lab. Inter2015; April.


  1. “Cardiovascular nanomedicine: challenges and opportunities” Godin B., T. Y. Hu., La Francesca S., Ferrari M. Molecular & Translational Vascular Medicine, edited by Dr. Monte Willis & Dr. Jonathon Homeister, 2011 Humana Press.

  2. “Morphology control of nanotextured drug carriers” T. Y. Hu., Lin K.. Mass transport of nanocarriers, edited by Dr. Rita Sedra, 2011 Pan Stanford Publishing Pte. Ltd.

  3. “Nanotechnology Towards Advancing Personalized Medicine” Sakamoto J. H., Godin B., T. Y. Hu., Blanco E., Van de Ven A, Vellaichamy A., Murphy M. B., La Francesca S., Schuenemeyer T., Given B., Meyn, A., Ferrari M. Handbook of Personalized Medicine: Advances in Nanotechnology, Drug Delivery and Therapy2011 Pan Stanford Publishing Pte. Ltd..

  4. “Circulating peptidome and tumor-resident proteolysis” Fan, J., Ning, B., Lyon, C., T. Y. Hu. Enzyme, edited by Dr. T. Y. Hu & Dr. fuyu Tamanoi, 2017 Springer Press.

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